INTISARI HAK PATEN EFEK TERAPEUTIK
TAHITIAN NONI BIOACTIVE BEVERAGE
Kekuatan ilmiah Tahitian Noni Bioactive Beverage yang tidak dimiliki oleh produk suplemen atau produk complementary and alternative Medicine (CAM) manapun adalah dianugerahai banyak hak paten Internasional yaitu 52 Sertifikasi Hak Paten International. Prestasi ini diluar kelaziman produk-produk nonfarmaseutikal, dan tentunya diluar persepsi publik kesehatan dewasa ini.
Sebagaimana fakta-fakta dilapangan (Kesaksian/ Testimoni) yang terjadi telah mengukuhkan spektrum manfaat terapeutik TNBB. Kondisi ini terjadi di Indonesia, perlahan namun pasti. Saat ini saja sudah beberapa guru besar fakultas kedokteran ternama di indonesia dan di luar negeri telah mengakui eksistensi TNBB dan merasakan manfaatnya langsung, tanpa pernah membantah kebenaran ilmiah yang terungkap dalam setiap naskah hak paten efek terapeutik baik secara in vitro dan in vivo yang di miliki oleh perusahaan Tahitian Noni International sebagai berikut :
Sebagaimana fakta-fakta dilapangan (Kesaksian/ Testimoni) yang terjadi telah mengukuhkan spektrum manfaat terapeutik TNBB. Kondisi ini terjadi di Indonesia, perlahan namun pasti. Saat ini saja sudah beberapa guru besar fakultas kedokteran ternama di indonesia dan di luar negeri telah mengakui eksistensi TNBB dan merasakan manfaatnya langsung, tanpa pernah membantah kebenaran ilmiah yang terungkap dalam setiap naskah hak paten efek terapeutik baik secara in vitro dan in vivo yang di miliki oleh perusahaan Tahitian Noni International sebagai berikut :
Berikut daftar hak paten yang telah dikantongi Tahitian Noni International
A. ANTINEOPLASTIC
Anti pembentukan jaringan baru
1. 1st Patent. Cancer Preventive Effect of Morinda citrifolia . International Publication Number WO 02/45654. Su, Chen et al. PCT 2002; p.1-20.
Pencegahan kanker.
2. 2nd Patent. Morinda citrifolia – Based Information for Inhibiting Metastasis of carcinogenic cells. International Publication Number WO 2004/098514. Su Chen et al. PCT 2004; p.1-32.
Penghambatan metastasis sel karsinogenik.
3. 3rd Patent. Anti-Angiogenesis Effect of Morinda citrifolia . International Publication Number WO 2004/041186. Palu, Afa et al. PCT 2004; p.1-24.
Anti pembentukan pembuluh darah yang abnormal terkait kasus kanker.
4. 4th Patent. Inhibition of Angiogenesis and Destruction of Angiogenic Vessel with Extracts of Noni Juice (Morinda citrifolia ). International Publication
Number WO/020296. Woltering Eugene et al. PCT 2003; p.1-47.
Noni Juice dapat menghambat terjadinya Angiogenesis dan merusak pembuluh darah Angiogenik.
5. 5th Patent . Morinda citrifolia L. Based Formulations for Inhibiting Matrix Metalloproteinase Enzymes.
United States Patent Application Ser. No. 20070184137. Palu, Afa et al. USPTO 2007
Menghambat enzim metalloproteinase yang dapat menyebabkan tumor.
6. 6th Patent. Synergistic Cancer Prevention Effect of Morinda citrifolia . International Application Number 2004/029896. Wang, Mian et al. PCT 2004; p.1-21.
Mencegah kanker.
7. 8th Patent. Preventative Effect of Morinda citrifolia on Mammary Breast Cancer. International Publication Number WO 2005/048919. Wang, Mian et al.PCT 2005; p.1-17.
Mencegah kanker payudara.
8. 9th Patent. Formulation and Methods for Treating Breast Cancer with Morinda citrifolia and Methylsulfonymethane. International Publication Number WO 2005/025410. Wang, Mian et al. PCT 2005; p.1-41.
Pengobatan dan pencegahan kanker payudara.
9. 10th Patent . Preventative and treatment effects of Morinda citrifolia as colon cancer cell growth inhibitor. United States Patent Application Ser. No. 7,070,813. Jasen, Jarake et al. USPTO 2006.
Mencegah dan menghambat pertumbuhan sel kanker usus.
10. 37th Patent. Preventative and Treatment Effects of Morinda citrifolia as an Aromatase Inhibitor. United States Patent Application Ser. No. 10/396,868. Palu, Afa et al. USPTO 2004; p.1-48.
Menghambat pembentukan enzim Aromatase terkait dengan penyakit yang berhubungan dengan hormon estrogen.
11. 53rd Patent. Method for Treating Carbon Tetra-Chloride Induced Liver Damage by Administering Morinda citrifolia . United States Patent Application Ser. No. 20030086990. Jensen Jarake et al. USPTO 2003; p.1-12.
Mengobati kerusakan liver akibat paparan CCl4 dari pestisida, fumigan, pernis, dll.
12. 54th Patent. Prostate Cancer. Patent pending in US (not yet publish).
Kanker Prostat
13. 55th Patent. Extract of the Noni Plant are Listed as Useful for Treatment of Cancer of the Stomach and Liver. JP 8208461. (not yet publish).
Ekstrak tanaman Noni untuk pengobatan kanker lambung dan liver
B. ANTI-INFLAMMATORY, ALLERGIC & ANTINONICEPTIVE
Anti-Inflamasi, Anti-alergi, dan Anti-noniseptif
14. 11th Patent. TAHITIAN NONI® JUICE on COX-1 and COX-2 and TAHITIAN NONI® Juice as a selective COX-2 Inhibitor. International Publication Number WO 02/45734. Su Chen et al. PCT 2002; p.1-14.
TAHITIAN NONI® JUICE sebagai inhibitor selektif COX-2
15. 12th Patent. Morinda citrifolia – Based Information 5-LOX and 15-LOX. International Publication Number WO 2005/ 120538. Palu, Afa et al. PCT 2005; p. 1-34.
Menghambat enzim 5-LOX dan 15-LOX terkait penyakit inflamasi
16. 13th Patent. Lipoxygenase and Cyclooxygenase Inhibition. International Publication Number WO 2008/067410. Deng, Sixhin et al. PCT 2008; p.1-31.
Menghambat enzim Lipoksigenase dan Siklooksigenase
17. 14th Patent. Morinda citrifolia Based Composition for Treatment of Anti-Inflammatory Diseases through Inhibition of COX-1, COX-2, Interleukin-1?, Interleukin-6, TNF-?, HLE, iNOS. International Publication Number WO 2007/076024. Zhou, Bing et al. PCT 2007; p.1-52.
Sebagai Anti-Inflamasi melalui penghambatan terhadap COX-1, COX-2, Interleukin-1?, Interleukin-6, TNF-?, HLE, iNOS.
18. 15th Patent. Morinda citrifolia Based Composition and Method for Inhibiting Xantine Oxidase. International Publication Number WO 2006/050012. Palu, Afa et al. PCT 2006; p.1-25.
Menghambat enzim Xantin Oksidase terkait dengan penyakit asam urat.
19. 16th Patent. Preventative and treatment effect of Morinda citrifolia on Osteoarthritis and Its Related Conditions. United States Patent Application Ser.No.7,033,624. Jesen, Jarake et al. USPTO 2006; p.1-21.
Pencegahan dan pengobatan osteoarthritis dan kondisi sejenisnya.
20. 17th Patent. Methods and Formulation for Inhibiting Naturally occurring Phosphodiesterase. United States Patent Application Ser.No.20070248701.
Menghambat terjadinya phosphodiesterase terkait dengan menurunnya energi tubuh, alergi dan asma.
C. ANTIFUNGAL/MICROBIAL & ANTIVIRAL
Anti-Jamur/Mikroba dan Anti Virus
21. 18th Patent. Morinda citrifolia Based Antifungal Formulation and Methods. International Publication Number WO 2006/104892. Isami, Fumiyuki et al.
Sebagai Anti-jamur.
22. 19th Patent. Antifungal Effects of Morinda citrifolia . International Publication Number WO 2003/099310. Gerson, Scott et al.
Efek sebagai anti-jamur.
23. 20th Patent. Formulation for Inhibiting Fungal and Microbial Growth Comprising Morinda citrifolia Puree Juice. United States Patent Application Ser.No.7,048,952.
Menghambat pertumbuhan jamur dan mikroba.
Menghambat pertumbuhan jamur dan mikroba.
24. 21st Patent. Methods and Formulation for Treating Candidiasis Using Morinda citrifolia . United States Patent Application Ser.No.7,014,873.
Pengobatan terhadap Candidiasis.
25. 22th Patent. Antiviral Morinda citrifolia L. Based Formulations and Methods of Administration. International Publication Number WO 2007/064601. Palu, Afa et al.
Metode pengobatan
26. 56th Patent. Use of Plant Extract from Noni for Treatment of Hepatitis B and AIDS. International Publication Number WO 88053043. (Not yet publish).
Ekstrak tanaman Noni untuk pengobatan Hepatittis B dan AIDS.
27. 57th Patent. Extract of Noni as Useful Treatment of Hepatitis. JP No.62132829. (Not yet publish).
Ekstrak noni untuk pengobatan Hepatitis.
28. 58th Patent. Extract of Noni as an Inhibitor of Proliferation of HIV. JP No.6087737. (Not yet publish).
Ekstrak noni sebagai penghambat proliferasi pada HIV.
29. 59th Patent. Extract of Noni Plant to Treat the Recurring Infection of the Upper Respiratory Tract Caused bu Helicobacter pylori . JP No.8217686. (Not yet publish).
Ekstrak tanaman noni untuk pengobatan Infeksi Saluran Pernafasan Atas (ISPA) yang disebabkan bakteri Helicobacter pylori.
D. DEGENERATIVE DISORDER & ADDICTION THERAPIES
Kerusakan Degeneratif & Terapi Adiksi
30. 25th Patent. Methods and Composition for Inhibiting Monoamine Oxidase and Catechol-O-Methyltransferase. International Publication Number WO 2005/086937. Palu, Afa et al.
Menghambat enzim Monoamine Oksidase (MAO) dan Cathechol-O-Methyltransferase (COMT) terkait dengan kerusakan mental dan syaraf.
Menghambat enzim Monoamine Oksidase (MAO) dan Cathechol-O-Methyltransferase (COMT) terkait dengan kerusakan mental dan syaraf.
31. 26th Patent. Methods and Composition for Reactivating Acetylcholinesterase. International Publication Number WO 2005/086834. Palu, Afa et al.
Mengaktifkan enzim Asetilkolinesterase terkait dengan sistem syaraf
32. 27th Patent. Morinda citrifolia Enhanced Naturaceutical Formulation and Method for Treating and Preventing Migraine Headaches. United States Patent Application Ser.No.20030108630. Story, Stephen et al.
Mengobati dan mencegah sakit kepala migrain.
33. 28th Patent. Method for Treating Visual Impairment through the Prophylactic Administration of Morinda citrifolia -Based Naturaceutical. United States Patent Application Ser.No.20030134002. Jensen,Jarake Ocampo Enreque.
Mengobati kerusakan visual (glaucoma, diabetes retinopathy, katarak, rabun senja, buta warna, dan sejenisnya).
34. 29th Patent. Nicotinic Acetylcholine Receptor Antagonist. United States Patent Application Ser.No.20060280818. Palu, Afa et al.
Antagonis reseptor Nikotin Asetilkolin terkait dengan kondisi kecanduan rokok/nikotin.
35. 30th Patent. Formulations and Methods for Preventing and Treating Substance Abuse and Addiction. United States Patent Application Ser.No.20070166416. Palu, Afa et al.
Mencegah dan mengobati penyalahgunaan obat dan adiksi terhadap obat.
36. 33rd Patent. Methods and Composition for Inhibiting Angiotensin Converting and Chymase Enzymes. International Publication Number WO 2005/086935.
Menghambat pembentukan Angiotensin dan enzim Chymase terkait dengan tekanan darah.
37. 46th Patent. Use of a Composition. International Publication Number WO 01/64231.
Penggunaan komposisi Morinda citrifolia.
38. 60th Patent. Histone Deacetylase and Tumor Necrosis Factor Converting Enzyme Inhibition. European Patent Application No.1726309. Palu, Afa et al. EP.
Menghambat Histone Deactylase (HDAC) dan Tumor Necrosis Converting Enzyme (TACE) terkait dengan tumor atau kanker.
E. INDUCE METABOLISM BALANCE & REPRODUCTION SYSTEM
Meningkatkan keseimbangan metabolisme & sistem reproduksi
39. 23rd Patent. Type II Diabetes. International Publication Number WO 2005/067489. Palu, Afa et al.
Diabetes tipe II.
40. 24th Patent. Preventative and Treatment Effects of Morinda citrifolia L. on Diabetes and Its Related Conditions. United States Patent Application Ser. No.7,186,422.
Mencegah dan mengobati Diabetes.
41. 61st Patent. A Palatable Noni Fruit Powder that Can be Use to Treat Diabetes, Heart Trouble, High Blood Pressure, Menstrual Problems, Fever, Aches, and Pains. States Patent Application Ser.No.5,288,491. USPTO. (Not yet publish).
Serbuk buah noni dapat untuk mengobati Diabetes, masalah jantung, hipertensi, masalah menstruasi, demam, dan nyeri.
42. 31st Patent. Morinda citrifolia Dietary Fiber. International Publication Number WO 01/15551. Wadsworth, John et al.
Sebagai serat diet.
43. 32nd Patent. Morinda citrifolia Based Formulation and Methods for Weight Management. International Publication Number WO 2007/064547. Palu, Afa et al. PCT.
Dapat untuk mengontrol berat badan.
44. 34th Patent. Composition and Methods for Reducing Oxysterol in Blood. International Publication Number WO 02/056899. Yegorova, I.
Mengurangi Oksiterol dalam darah terkait kadar kolesterol dan tekanan darah.
45. 35th Patent. Improving Profiles of Lipid Protein and Inhibiting HMG-CoA Reductase. International Publication Number WO 2005/069844. Palu, Afa et al. PCT.
Memperbaiki profil Lipid Protein (LDL dan HDL) dan menghambat enzim HMG-CoA reduktase.
46. 36th Patent. Selectively Inhibiting Estrogen Production and Providing Estrogenic Effects in the Human Body. International Publication Number WO 2004/091545.
Menghambat secara selektif produksi hormone estrogen terkait dengan kanker payudara.
47. 38th Patent. Use of Morinda citrifolia (Noni) Extract in the field of Spermatology and Method for Improving Sperm Preservation. International Publication Number WO 2008/032132. Kutvolgyi, Gabriella.
Digunakan dalam bidang spermatologi dan metode untuk meningkatkan daya tahan sperma.
48. 39th Patent. Composition for Increasing Levels of Hormones and a Method for Preparation of Said Composition.International Publication NumberWO 2005/084681.
Meningkatkan kadar hormon Testosteron dan hormon pertumbuhan.
F. ORAL CARE & DERMATOLOGICAL THERAPIES
Terapi oral dan dermatological
49. 40th Patent. Morinda citrifolia Based Oral-Care Composition and Methods. International Publication Number WO 2005/030141. Jesen, Jarake et al. PCT 2005; p.1-60.
Untuk perawatan oral (untuk kesehatan gigi dan gusi).
50. 41st Patent. Use of Noni in Relation to Oral Pathologies for Example in order to Combat Problems Associated with Asialia and Hyposilia. International Publication Number WO 2005/018655. Vein Jean, D’arros Gerard. PCT 2005; p.1-20.
Pengobatan penyakit oral.
51. 42nd Patent. Methods and Composition for Treating Dermatological Disorder with Morinda citrifolia . United States Patent Application Ser.No.20030091666. Murad Howard et al. USPTO 2003; p.1-20.
Pengobatan kerusakan dermatologi (masalah kulit).
52. 43rd Patent. Cosmetic intensive repair serum with Morinda citrifolia . United States Patent Application Ser.No.6,589,514. Jensen Jarake, et al. USPTO 2003; p.1-21.
Untuk kosmetik, sebagai repair serum.
53. 44th Patent. Morinda citrifolia Enhanced Lip Treatment. United States Patent Application Ser.No.20030086989. Jensen Jarake, Robinson Heidi. USPTO 2003; p.1-12.
Untuk perawatan bibir.
G. THERAPEUTIC & PALLIATIVE JUICE COMPOSITION
Terapi jus & Paliatif
54. 45th Patent. Therapeutic Juice Composition for Woman. United States Patent Application Ser.No.20070122502. Lawrence M. USPTO 2007; p.1-12.
54. 45th Patent. Therapeutic Juice Composition for Woman. United States Patent Application Ser.No.20070122502. Lawrence M. USPTO 2007; p.1-12.
Jus terapi untuk wanita.
55. 47th Patent. Morinda citrifolia Leaf Juice and Leaf Extract Based Formulations. International Publication Number WO 2007/064521. Palu Afa et al. PCT 2007; p.1-47.
Jus daun dan ekstrak daun Morinda citrifolia
56. 48th Patent. Method and Composition for Administering Bioactive Compounds Derived from Morinda citrifolia . International Publication Number WO 2007/134205. Zhou Bing et al. PCT 2007; p.1-27.
Pemberian senyawa bioaktif dari Morinda citrifolia
57. 49th Patent. Noni Extract for Prevention of Disease. United States Patent Application Ser.No.20030004116. Ghai Gheetha et al. USPTO 2003; p.1-8.
Ekstrak noni untuk pencegahan penyakit (antara lain : Hipertensi, asma, diabetes, kram haid, diare & penyakit pada saluran kencing dan nafas).
58. 50th Patent. Palliative Effects of Morinda citrifolia Oil and Juice. International Publication Number WO 02/083159. Jensen Jarake et al. PCT 2003; p.1-14.
58. 50th Patent. Palliative Effects of Morinda citrifolia Oil and Juice. International Publication Number WO 02/083159. Jensen Jarake et al. PCT 2003; p.1-14.
Efek paliatif Morinda citrifolia terkait penyakit kanker, Alzheimer, penyakit berbasis inflamasi.
59. 62nd Patent. A Method of for Processing the Noni Plant into a Powder. United States Patent Application Ser.No.5,288,491. Moniz. USPTO 2004. (Not yet publish).
Metode untuk proses tanaman Noni menjadi serbuk.
60. 63rd Patent. Extract of Noni Fruit for Use as a Health-Improving Drink or Dietary Supplement. FR No. 2783137. (Not yet publish).
60. 63rd Patent. Extract of Noni Fruit for Use as a Health-Improving Drink or Dietary Supplement. FR No. 2783137. (Not yet publish).
Ekstrak noni sebagai minuman berenergi atau suplemen makanan.
H. MOLECULAR MECHANISM of XERONINE & ANTIOXIDANT
Mekanisme molekuler dari xeronin & anti-oksidan
61. 51st Patent. Reducing Cellular Damage in the Human Body. International Publication Number WO 02/43664. Su Chen et al. PCT 2002; p.1-14.
Mengurangi kerusakan sel dalam tubuh.
62. 52nd Patent. Xeronine, a New Alkaloid, Useful in Medical, Food and Industrial Fields. United States Patent Application Ser.No. 4,543,212. Heincke, Ralph. USPTO 1985; p.1-28.
Xeronine, berguna dalam bidang kesehatan, makanan, dan industri.
63. 7th Patent. Inhibitory and Preventative Effects of Processed Morinda citrifolia on mutagenesis and carcinogenesis in mammals. United States Patent Application Ser.No.2003157205. Jensen, Jarake et al. USPTO 2003; p.1-25.
Menghambat dan mencegah proses mutagenesis dan karsinogenesis
Daftar Patent Tahitian Noni International juga bisa dilihat di website penerbit paten ybs:
World International Property Organization
United States Patent and Trademark Office
Intelectual Property Australia
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